Akwɛ niŋmaa nɛɛ mli yɛ Science X lɛ niŋmaa gbɛjianɔtoi kɛ mlai anaa. Niŋmalɔi lɛ ema sui ni nyiɛ sɛɛ nɛɛ anɔ mi yɛ be mli ni amɛkwɛɔ koni nɔ ni yɔɔ mli lɛ afee nɔ ni ja:
Fungi kɛ helai ni gbeɔ mɔ lɛ kponɔgbɛ fã ni shwieɔ shi, ni atsɛɔ lɛ “extracellular matrix” loo ECM lɛ yɛ jeli ni tamɔ nɔ ni etsuɔ ​​nii akɛ nɔ ni buɔ mɔ he kɛ ŋmei. Shi taakɛ nikasemɔ ko ni afee nyɛsɛɛ nɛɛ ni akala awo wolo tɛtrɛɛ ni ji iScience lɛ mli, ni Massachusetts Amherst Yunivɛsiti lɛ kɛ Worcester Polytechnic Institute lɛ fee ekome kɛfee lɛ tsɔɔ lɛ, ECM ni yɔɔ nibii bibii komɛi amli lɛ feɔ gel yɛ oxalic acid loo acid krokomɛi ni yɔɔ mlɛo pɛ mli. 1449240174198-2′); });
Akɛni ECM tsuɔ gbɛfaŋnɔ ko ni he hiaa waa he nii yɛ nɔ fɛɛ nɔ mli kɛjɛ tsofai ni gbeɔ helai ni gbeɔ helai lɛ anɔ kɛyashi paipii ni etsi kɛ tsofafeemɔ he nibii amli mujiwoo nɔ hewɔ lɛ, bɔ ni helai bibii ni wala yɔɔ amɛmli lɛ tsuɔ amɛ sticky gel layers lɛ ahe nii amɛhaa lɛ shishinumɔ yɛ shishinumɔi babaoo yɛ wɔ daa gbi shihilɛ mli.
Barry Goodell, ni ji nibii bibii ni wala yɔɔ mli lɛ ahe nilelɔ yɛ Massachusetts Amherst Yunivɛsiti lɛ, ni ji wolo lɛ ŋmalɔ nukpa lɛ kɛɛ akɛ: “Miyɛ ECM ni ji nibii bibii ni yɔɔ mli lɛ ahe miishɛɛ be fɛɛ be. "Bei pii lɛ, mɛi susuɔ ECM he akɛ eji kponɔgbɛ nɔ ko ni buɔ nibii bibii ahe. Shi ebaanyɛ etsu nii hu akɛ gbɛ ni haa niyenii mli hewalɛ kɛ enzymes boteɔ nibii bibii amli wala yibii lɛ amli ni amɛjeɔ kpo."
Nɔ ni akɛwoɔ nɔ lɛ tsuɔ nitsumɔi srɔtoi ahe nii: bɔ ni ekɛ ehe kpɛtɛɔ he lɛ tsɔɔ akɛ, nibii bibii aŋkroaŋkroi baanyɛ abua amɛhe naa ni amɛfee coloni loo “biofilms”, ni kɛ́ nibii bibii ni fa bɔ ni sa fee enɛ lɛ, ebaanyɛ etsĩ paipii amli loo efite tsofafeemɔ he nibii.
Shi esa akɛ ŋshɔŋloo lɛ hu afee nɔ ni nu tsɔɔ mli. Nibii bibii babaoo ni wala yɔɔ amɛmli lɛ jieɔ enzymes srɔtoi kɛ nibii krokomɛi ni tsakeɔ amɛhe kɛtsɔɔ ECM lɛ nɔ kɛyaa nibii ni amɛsumɔɔ ni amɛye loo amɛwo mli lɛ amli (tamɔ tso ni egbo loo kooloi ni yɔɔ sɛɛgbɛ lɛ ahe fãji), ni no sɛɛ lɛ, kɛ́ enzymes lɛ gbe amɛ niyenii ni shwieɔ shi lɛ he nitsumɔ lɛ naa lɛ, amɛjieɔ niyenii mli nibii lɛ kɛtsɔɔ ECM lɛ nɔ. ajieɔ tsofa ni akɛwoɔ mli lɛ ekoŋŋ kɛyaa gbɔmɔtso lɛ mli. matriks ni yɔɔ wala yibii krokomɛi amli.
Enɛ tsɔɔ akɛ ECM jeee nɔ ko ni buɔ mɔ he ni bɛ hewalɛ kɛkɛ; Yɛ anɔkwale mli lɛ, taakɛ Goodell kɛ enanemɛi tsɔɔ lɛ, etamɔ nɔ ni nibii bibii ni wala yɔɔ amɛmli lɛ yɛ nyɛmɔ ni amɛkɛkudɔɔ bɔ ni amɛ ECM lɛ shwieɔ shi ehaa lɛ, ni no hewɔ lɛ amɛnyɛɔ amɛtsɔɔ mli. Mɛɛ gbɛ nɔ amɛtsɔɔ amɛfeɔ lɛ? Mfoniri lɛ he gbɛjianɔtoo: B. Goodell
Yɛ ŋmeii amli lɛ, etamɔ nɔ ni nɔ ni jɛɔ mli baa lɛ ji oxalic acid, ni ji tsofa ko ni afɔɔ namɔ yɛ tsei babaoo amli. Taakɛ Goodell kɛ enanemɛi lɛ na lɛ, etamɔ nɔ ni helai bibii babaoo kɛ oxalic acid ni amɛjieɔ lɛ tsuɔ nii ni amɛkɛkpɛtɛɔ carbohydrates ni yɔɔ kponɔgbɛ lɛ he, ni amɛfeɔ ECM ni tamɔ gel ni shwieɔ shi.
Shi beni kuu lɛ kwɛ mli jogbaŋŋ lɛ, amɛna akɛ jeee akɛ oxalic acid lɛ yeɔ ebuaa ni afeɔ ECM kɛkɛ, shi moŋ “ekwɛɔ nɔ” hu: bɔ ni oxalic acid babaoo ni helai bibii lɛ kɛfataa carbohydrate-acid ni akɛfutuɔ lɛ he lɛ, nakai ECM lɛ feɔ ŋmɔlɔŋmɔlɔ. Babaoo ni ECM lɛ feɔ ŋmɔlɔŋmɔlɔ lɛ, babaoo ni etsĩɔ molekulii wuji anaa koni amɛkabote loo amɛje mli, yɛ be mli ni molekulii bibii lɛ hiɔ shi ni amɛboteɔ helatsɛmɛi amli kɛjɛɔ shihilɛ mli, ni nakai nɔŋŋ eji yɛ sɛɛ mli hu.
Nɛkɛ nii ni ana nɛɛ teɔ blema jeŋ nilee shishinumɔ ni kɔɔ bɔ ni nibii srɔtoi ni ŋmeii kɛ helai bibii jieɔ lɛ kɛjɛɔ nɛkɛ nibii bibii nɛɛ amli kɛyaa shihilɛ mli lɛ he lɛ shi. Goodell kɛ enanemɛi wo ŋaa akɛ yɛ shihilɛi komɛi amli lɛ, ekolɛ ehe baahia ni nibii bibii ni wala yɔɔ amɛmli lɛ kɛ amɛhe afɔ̃ nibii bibii ni ajieɔ lɛ kpo lɛ anɔ babaoo koni amɛtutua matriks loo fãji ni nibii bibii ni wala yɔɔ amɛmli lɛ damɔɔ nɔ koni amɛhi shi loo amɛná hela lɛ.
Enɛ tsɔɔ akɛ, nibii bibii ni ajieɔ lɛ kpo lɛ hu baanyɛ atsu gbɛfaŋnɔ ko ni he hiaa waa yɛ helai ahe nitsumɔ mli kɛji akɛ enzymes wuji nyɛɛɛ atsɔ nibii bibii ni yɔɔ wala yibii lɛ amli lɛ amli.
Goodell kɛɛ akɛ: “Etamɔ nɔ ni gbɛ ko yɛ ni yɔɔ teŋgbɛ, ni nibii bibii ni wala yɔɔ amɛmli lɛ baanyɛ akudɔ bɔ ni acidity lɛ yɔɔ ha lɛ koni amɛtsake amɛhe amɛwo shihilɛ pɔtɛɛ ko mli, ni amɛhiɛ molecules wuji lɛ ekomɛi, tamɔ enzymes lɛ amli, yɛ be mli ni amɛhaa molecules bibii lɛ tsɔɔ ECM lɛ mli mlɛo.
Oxalic acid ni akɛtsakeɔ ECM lɛ baanyɛ afee gbɛ ni nibii bibii ni wala yɔɔ amɛmli lɛ tsɔɔ nɔ amɛbuɔ amɛhe kɛjɛɔ tsofai ni gbeɔ helai kɛ tsofai ni gbeɔ helai lɛ ahe, ejaakɛ tsofai nɛɛ ateŋ babaoo ji tsofai ni dara waa. Nɛkɛ nyɛmɔ ni akɛfeɔ nɔ ko bɔ ni sa nɛɛ ji nɔ ni baanyɛ afee nɔ titri ni baaha aye gbɛtsii nii wuji ni yɔɔ tsofafeemɔ ni gbeɔ helai lɛ ateŋ ekome nɔ kunim, ejaakɛ ECM lɛ ni akɛtsuɔ nii koni eha etsɔ mli jogbaŋŋ lɛ baanyɛ aha tsofai ni gbeɔ helai kɛ tsofai ni gbeɔ helai lɛ atsu nii jogbaŋŋ.
Goodell kɛɛ akɛ: “Kɛ́ wɔbaanyɛ wɔkudɔ biosynthesis kɛ acid bibii tamɔ oxalate ni yɔɔ helai bibii komɛi amli lɛ, wɔbaanyɛ wɔkudɔ nɔ ni yaa helai bibii lɛ amli lɛ hu, ni baanyɛ aha wɔtsa helai babaoo ni jɛɔ helai bibii amli lɛ jogbaŋŋ.”
Nibii krokomɛi ni kɔɔ he: Gabriel Perez-Gonzalez kɛ ekrokomɛi, Oxalates kɛ beta-glucan nitsumɔ: nɔ ni jɛɔ mli baa kɛha tsɛŋemɔ hela ni haa mɔ he jɔ̃ɔ ehe kɛ tsɛŋemɔ hela ni haa mɔ he jɔɔ lɛ, iScience (2023). DOI: 10.1016/j.isci.2023.106851
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